| 摘要 |
<p>Compounds of the formula <FORM:1066926/C2/1> and their acid addition salts, in which R1 is an aryl group optionally substituted one or more halogen atoms, C1- 6 alkyl, C1- 6 alkoxy or CF3 groups, R11 is an alkyl group or an aralkyl group optionally substituted in the aryl residue by one or more halogen atoms, CF3, C1- 6-alkyl or C1- 6-alkoxy groups; R111 is H or a C1- 6-alkyl group and A is an ethylene group optionally substituted by one or more C1- 6-alkyl groups, are prepared either by subjecting a compound of the formula <FORM:1066926/C2/2> in which X is a halogen atom, to intramolecular condensation or by reacting a 2-mercapto-2-thiazoline with an appropriate hydrazine. The starting material may be prepared in situ by reacting an optionally substituted b -X-ethyl-thiocyanate in which X is a halogen atom with an appropriate hydrazine. Pharmaceutical compositions, useful as hypertensive agents and vasoconstrictors, comprise the compounds of the invention and an inert carrier therefor and may be administered either orally or parenterally.</p> |
