| 发明名称 | Induced activation in dendritic cells | ||
| 摘要 | The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide. | ||
| 申请公布号 | US8999949(B2) | 申请公布日期 | 2015.04.07 |
| 申请号 | US201313786339 | 申请日期 | 2013.03.05 |
| 申请人 | Baylor College of Medicine | 发明人 | Spencer David;Hanks Brent;Slawin Kevin |
| 分类号 | A61K48/00;C12N5/10;A61K38/17;A61K39/00;A61K39/12;C12N5/16 | 主分类号 | A61K48/00 |
| 代理机构 | Grant IP, Inc. | 代理人 | Grant IP, Inc. |
| 主权项 | 1. A method for inducing an immune response in vivo, which comprises administering to a subject a polynucleotide comprising a promoter operably linked to a nucleotide sequence that encodes a chimeric protein and a polynucleotide comprising a nucleotide sequence that encodes an antigen, wherein the chimeric protein comprises a membrane targeting region, a multimeric ligand binding region and a CD40 cytoplasmic polypeptide region lacking the CD40 extracellular domain, whereby an immune response is induced. | ||
| 地址 | Houston TX US | ||