| 发明名称 | Glucocorticoid induced leucine zipper mimetics as therapeutic agents in multiple sclerosis | ||
| 摘要 | Polypeptide compositions that mimic the activity of glucocorticoid induced leucine zipper (GILZ) on the immune system are described. Also described is a method of treating multiple sclerosis using compositions comprising GILZ or lower molecular weight polypeptides with structural relationships to GILZ. | ||
| 申请公布号 | US8999937(B2) | 申请公布日期 | 2015.04.07 |
| 申请号 | US201214001716 | 申请日期 | 2012.02.28 |
| 申请人 | Indiana University Research and Technology Corporation | 发明人 | Srinivasan Mythily |
| 分类号 | C07K14/47;A61K38/07;A61K38/08;A61K38/10;A61K38/16 | 主分类号 | C07K14/47 |
| 代理机构 | Barnes & Thornburg LLP | 代理人 | Barnes & Thornburg LLP |
| 主权项 | 1. A pharmaceutical composition comprising a polypeptide from 6 to 35 amino acid residues, the polypeptide comprising 1 to 3 tetrapeptides having the sequence of PXXP, wherein P is proline; and X is any amino acid, and wherein the polypeptide comprises the amino acid sequence of CLSPEEPAPESPQVPEAPGGSAV (SEQ ID NO: 6), and wherein the pharmaceutical composition further comprises a cell penetrating peptide, wherein the polypeptide and the cell penetrating peptide form a complex. | ||
| 地址 | Indianapolis IN US | ||