| 发明名称 | Anti-GCC antibody molecules and methods for use of same | ||
| 摘要 | Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein. | ||
| 申请公布号 | US9000129(B2) | 申请公布日期 | 2015.04.07 |
| 申请号 | US201313872080 | 申请日期 | 2013.04.27 |
| 申请人 | Millennium Pharmaceuticals, Inc. | 发明人 | Frank Helen Alison;McDonald Alice A.;O'Keefe Theresa L. |
| 分类号 | C07K16/40;C07K16/28;G01N33/574 | 主分类号 | C07K16/40 |
| 代理机构 | Lando & Anastasi LLP | 代理人 | Lando & Anastasi LLP |
| 主权项 | 1. An anti-GCC antibody molecule comprising a light chain variable region and a heavy chain variable region, wherein the light chain variable region and the heavy chain variable region are selected from: the light chain variable region of antibody MIL-44-148-2 according to SEQ ID NO: 13, the heavy chain variable region of antibody MIL-44-148-2 according to SEQ ID NO: 11, the light chain variable region of antibody MIL-44-67-4 according to SEQ ID NO: 17, and the heavy chain variable region of antibody MIL-44-67-4 according to SEQ ID NO: 15. | ||
| 地址 | Cambridge MA US | ||