Amla extract for transdermal application

摘要

An extract of Emblica officinalis (Amla). Transdermal formulation having an extract of Emblica officinalis having exhibiting greater migration of Vitamin C across a skin surface as compared to a transdermal formulation having Vitamin C without the extract. Extract of Emblica officinalis exhibiting greater migration of H+ ions across a skin surface as compared to a transdermal formulation having Vitamin C alone. A transdermal formulation having an extract of Emblica officinalis. Method of preparing an extract of Emblica officinalis.

主权项

1. A method of increasing transfer of Vitamin C across a skin surface of a subject in need thereof, the method comprising, administering a transdermal formulation comprising an extract Emblica officinalis fruit,
wherein the extract of Emblica officinalis fruit comprises, by weight, about 35±5% of of galloellagitannin; about 1-9% of Vitamin C; and, about 5-60 of carbohydrate, wherein about 0.5-5% of the galloellagitannin is comprised of corilagin, wherein about 2-25 % of the carbohydrate is comprised of soluble fiber, and wherein the extract of Emblica officinalis fruit is prepared by a process comprising: pulping fruits of Emblica officinalis in water to obtain a slurry, centrifuging the slurry to obtain a supernatant, passing the supernatant through a strong H+ ion exchange resin to obtain a permeate, wherein the permeate is said extract of Emblica officinalis.