摘要 |
The present disclosure relates to compositions and methods for destabilizing biofilms, altering biofilm 3D structure, and dispersing biofilms, in order to enhance biofilm cell removal and/or sensitivity to other agents (e.g., environmental or co-applied treatments). In particular, the present disclosure relates to the use of L-arginine in the removal and/or sensitization (e.g., to antimicrobials) of microorganisms in medical, industrial, domestic, or environmental applications, as well as treatment of bacterial infections (e.g., in biofilms). |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;UNIVERSITY OF NEWCASTLE UPON TYNE |
发明人 |
RICKARD, ALEXANDER;JAKUBOVICS, NICK;SAMARIAN, DEREK, S.;KOLDERMAN, ETHAN |