| 发明名称 |
HIGH PURITY HEPARIN AND PRODUCTION METHOD THEREFOR |
| 摘要 |
The present invention provides a high purity heparin useful to be a pharmaceutical product, cosmetics, research reagent, or the like, and a method for producing the same, more specifically, a heparin which does not substantially contain a nitrous acid degradation-resistant impurity and a method for producing a heparin, comprising mixing an aqueous solution of 5 to 30% by weight of the heparin with ethanol having an amount (volume) 0.2 to 1 times the amount (volume) of the aqueous heparin solution to obtain a colloidal precipitate of heparin. |
| 申请公布号 |
US2015094460(A1) |
申请公布日期 |
2015.04.02 |
| 申请号 |
US201414565671 |
申请日期 |
2014.12.10 |
| 申请人 |
University of Miyazaki ;Fuso Pharmaceuticals Industries, Ltd. |
发明人 |
Muguruma Michio;Murata Hiroshi |
| 分类号 |
C08B37/00 |
主分类号 |
C08B37/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A heparin which does not substantially contain a nitrous acid degradation-resistant impurity,
wherein with respect to the peak total area value of the heparin obtained when the heparin is analyzed by high performance liquid chromatography (HPLC), the peak total area value appearing at the elution point of the heparin when degraded with nitrous acid and analyzed by HPLC under the same condition is 5% or less. |
| 地址 |
Miyazaki-shi JP |
