Solid dosage form that promotes reliable oral, esophageal and GI transit

摘要

A solid dosage form designed to facilitate rapid and reliable oral, esophageal and GI transit has a surface area of the contact patch, i.e., the area of contact between the dosage form and the bodily surface reduced. The dosage form can be an asymmetric oral dosage unit containing a bioactive, the dosage unit being asymmetric with respect to a rotational axis perpendicular to a longitudinal axis of the dosage form, the rotational axis being located substantially at a mid point along the longitudinal axis. The dosage unit may have an outer surface ridged or dimpled or have at least one annular ring so as to reduce the contact patch of the dosage unit with a flat surface compared to non-ridged dosage unit of the same size and shape. The oral dosage unit can also have a spherical shape with or without ridges and/or dimples. Dies for forming these oral dosage units have, in a closed state, a cavity having a shape corresponding to the oral dosage unit.

主权项

1. An asymmetric oral dosage unit containing a bioactive at least within the dosage unit selected from the group consisting of a pharmaceutical, biological, antigen, botanical, food, nutraceutical, cosmaceutical and gene therapeutic, the dosage unit having a length along its longitudinal axis longer than a length along all axes perpendicular to the longitudinal axis and being asymmetric with respect to a rotational axis perpendicular to the longitudinal axis of the dosage form, the rotational axis being located substantially at a mid point along the longitudinal axis, the asymmetry being configured to reduce the contact patch of the dosage unit with a flat surface and decrease esophageal transit time when orally administered compared to a dosage unit of the same size but that is symmetric with respect to said rotational axis.