| 主权项 |
1. A peptide of general formula (I)
R1—Wn—Xm-AA1-AA2-AA3-AA4-Yp—Zq—R2 (I) its stereoisomers, mixtures thereof and/or its cosmetically or pharmaceutically acceptable salts, wherein:
AA1 is -His-;AA2 is selected from the group consisting of -His-, -Leu- and -Pro-;AA3 is -Leu-;AA4 is selected from the group consisting of -Arg- and -Asn-;W, X, Y and Z are independently selected from amongst themselves from the group consisting of the codified amino acids and uncodified amino acids;n, m, p and q are independently selected from amongst themselves and have a value between 0 and 1; n+m+p+q is less or equal to 2;
R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO— wherein R5 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl;R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3, wherein R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl;with the proviso that when AA2 is -Leu-, AA4 is -Asn- and Y is -Gln- then Z is not -Leu-;and with the proviso that when AA2 is -His-, AA4 is -Arg- and Y or Z are -Tyr- then p+q is not 1, wherein when R1 or R5 is a substituted non-cyclic aliphatic group or substituted aralkyl group, each substituent of said substituted non-cyclic aliphatic group or substituted aralkyl group is selected from the group consisting of hydroxyl, C1-C4 alcoxyl, C1-C4 oxycarbonyl, halogen, cyano, nitro, azido, C1-C4 alkylsulfonyl, thiol, C1-C4 alkylthio, aryloxyl, and —NRb(C=NRb)NRbRc, where Rb and Rc are independently selected from the group consisting of H, C1-C4 alkyl, C2-C4 alkenyl_C2-C4 alkynyl_C3-C10 cycloalkyl, C6-C18 aryl, C7-C17 aralkyl, and 3-10-membered-heterocyclyl, and wherein when R3 or R4 is a substituted non-cyclic aliphatic group, substituted heterocyclyl group, substituted heteroarylalkyl group, or substituted aralkyl group, each substituent of said substituted non-cyclic aliphatic group, substituted heterocyclyl group, substituted heteroarylalkyl group, or substituted aralkyl group is selected from the group consisting of hydroxyl, C1-C4 alcoxyl, amino, C1-C4 aminoalkyl, C1-C4 carbonyloxyl, halogen, cyano, nitro, azido, C1-C4 alkylsulfonyl, thiol, C1C4 alkythio, aryloxyl, and —NRb(C=NRb)NRbRc , where Rb and Rc are independently selected from the group consisting of H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C10 cycloalkyl, C6-C18 aryl, C7-C17 aralkyl 3-10-membered-heterocyclyl. |
