Devices, systems, and methods for determining isometric and isotonic activity of luminal organs

摘要

Devices, systems, and methods for determining isometric and isotonic activity of luminal organs. In an exemplary method for detecting a luminal organ response to mechanical stimulation of the present disclosure, the method comprises the steps of maintaining a luminal organ at a first internal pressure, increasing the first internal pressure of the luminal organ, and measuring a first organ parameter change in response to the increase in internal pressure. In an exemplary system for detecting a luminal organ response to mechanical stimulation of the present disclosure, the system comprises a first conduit having a proximal end, a distal end, and a lumen therethrough, the distal end sized and shaped to fit within a luminal organ, a pressure transducer, and at least one pressurized vessel capable of introducing a fluid into the lumen of the first conduit, wherein the first conduit, the pressure transducer, and the at least one pressurized vessel are either directly or indirectly coupled to one another so that a pressure of a fluid present within the first conduit can be measured using the pressure transducer.

主权项

1. A system for detecting a luminal organ response to mechanical stimulation, the system comprising:
a first conduit and a second conduit each having a proximal end, a distal end, and a lumen therethrough, the distal ends each sized and shaped to fit within a luminal organ and configured to maintain the luminal organ at a first length within a chamber for receiving a fluid and the luminal organ; a pressure transducer in communication with at least one of the first conduit and the second conduit and configured to measure an internal pressure within the luminal organ; and a volume compensator coupled to the first conduit and operable to inject a liquid into the luminal organ so that the liquid increases the internal pressure within the luminal organ in response to a decrease in the internal pressure within the luminal organ as identified by the pressure transducer and to maintain at or near an isovolumic state within the luminal organ; wherein the system is configured so that the luminal organ is closed to axial flow conditions therethrough; wherein the system is operable to measure a change to the internal pressure within the luminal organ resulting from a luminal organ response; and wherein, when the internal pressure is at or near an established set point, the volume compensator does not automatically remove fluid from the luminal organ in response to an increase in the internal pressure.