Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them

摘要

In one general aspect of the present invention, pharmaceutical formulations comprising both a proton pump inhibitor microencapsulated or dry coated with a material that enhances the shelf-life of the pharmaceutical composition and one or more antacid are described. In another general aspect of the present invention, pharmaceutical formulations comprising both a proton pump inhibitor microencapsulated or dry coated with a taste-masking material and one or more antacid are described.

主权项

1. A solid pharmaceutical composition having an enhanced shelf-life, comprising:
(a) about 1 to about 120 mg of omeprazole, or a free base, free acid, salt, enantiomer, isomer, or tautomer, thereof, in combination with sodium bicarbonate, wherein said combination is microencapsulated with a material that enhances the shelf-life of the pharmaceutical composition comprising at least one cellulose hydroxypropyl ether; and (b) about 1 to about 160 mEq of antacid comprising sodium bicarbonate wherein the pharmaceutical composition is not enteric coated and has less than 5% total new impurities after 1 year of storage at room temperature.