| 发明名称 | Compositions and method for treatment of ischemic neuronal reperfusion injury | ||
| 摘要 | A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like. | ||
| 申请公布号 | US8993512(B2) | 申请公布日期 | 2015.03.31 |
| 申请号 | US201414273343 | 申请日期 | 2014.05.08 |
| 申请人 | Howard University | 发明人 | Mangat Harpal S.;Karla Pradeep K. |
| 分类号 | A61K38/00;A61K47/00;A61K31/4178;C07D405/12;A61K45/06;A61K38/05;A61K31/13;A61K31/40;A61K31/5513;A61K31/5517 | 主分类号 | A61K38/00 |
| 代理机构 | Fitch, Even, Tabin & Flannery, LLP | 代理人 | Fitch, Even, Tabin & Flannery, LLP |
| 主权项 | 1. A method of treatment of neuronal reperfusion injury with ischemic neuropathy, the method comprising: administering an effective amount of at least one of a compound having the formulas I, II or III | ||
| 地址 | Washington DC US | ||