Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof

摘要

The disclosure provides deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide (deuterated laquinimod), its salts, pharmaceutical compositions comprising them and uses. Disclosed uses include treatment of autoimmune diseases such as Multiple Sclerosis, Systemic Lupus Erythematosus, lupus nephritis, lupus arthritis, Crohn’s Disease or Rheumatoid arthritis.