发明名称 |
Method for enhancing engraftment of haematopoetic stem cells |
摘要 |
<p>Disclosed is a composition comprising at least one prostacyclin analogue together with an unspecific cAMP activating agent and stimulated haematopoietic stem cells. Also disclosed is a method for enhancing engraftment of haematopoietic stem cells (HSCs) by an ex vivo pretreatment of the HSCs which comprises the following steps: a. using a sample containing haematopoietic stem cells; b. admixing to said sample at least one prostacyclin analogue to obtain a mixture; c. incubating said mixture for a period of time sufficient to stimulate G alpha-s-signalling in said cells. Further disclosed is the use of a composition comprising at least one prostacyclin analogue in the production of a composition for the treatment of individuals suffering from bone marrow disease transplanted with haematopoietic stem cells prepared according to the above method.</p> |
申请公布号 |
NZ612450(A) |
申请公布日期 |
2015.03.27 |
申请号 |
NZ20120612450 |
申请日期 |
2012.01.13 |
申请人 |
SCIPHARM SÀRL |
发明人 |
ZEBEDIN-BRANDL EVA-MARIA;HUSSAIN FILZA;BERGMAYR CHRISTIAN;FREISSMUTH MICHAEL |
分类号 |
A61K31/5585;A61K35/28;C12N5/078 |
主分类号 |
A61K31/5585 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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