FERMENTATION PROCESS

摘要

A methods for altering the metabolite profile of a fermentation, by increasing flux through acetolactate. The methods comprises increasing production of one or more products derived from acetolactate. Further provided is a method for increasing the production of 2,3-butandiol by microbial fermentation of gaseous substrates, the method comprising providing a compound which inhibits one or more enzymes which convert acetolactate to branched chain amino acids to the fermentation. The present invention further provides methods for increasing the production of 2,3-butandiol relative to other fermentation products such as ethanol and acetic acid.

主权项

1. A method of increasing the production of at least one product derived from acetolactate, the method comprising:
a. providing a gaseous substrate comprising CO to a bioreactor comprising a culture of at least one acetogenic carboxydotrophic microorganisms in a liquid nutrient medium, to produce at least one fermentation product; and b. inhibiting the flux of carbon to branched chain amino acids.