Self Assembled Films for Protein and Drug Delivery Applications

摘要

Provided are systems for controlled release of proteins from decomposable thin films constructed by layer-by-layer deposition. Such films generally comprise alternating layers of polymers and proteins, and may further comprise additional layers of polyions. In some embodiments, decomposable thin films and methods of using such films allow proteins to be released over an extended period of time and/or retention of as much as 100% of function of released protein.

主权项

1. A decomposable thin film comprising at least one tetralayer unit, the tetralayer unit comprising:
a degradable polyelectrolyte layer having a first electrostatic charge; a first polysaccharide layer disposed next to the degradable polyelectrolyte layer, the polysaccharide layer having a second electrostatic charge, the first and second electrostatic charges being opposite; a carrier layer disposed next to the first polysaccharide layer, the carrier layer including at least one growth factor; and a second polysaccharide layer disposed next to the carrier layer.