| 主权项 |
1. A compound having a structure according to Formula I:or a pharmaceutically accept able salt thereof, wherein:
Y is O or S; L is selected from the group consisting of a direct bond, —CR7R8—, —C(O)—, —O—, —S(O)z—, —NR9—, —CR7R8—CR10R11—, —CR7R8—C(O)—, —CR7R8—O—, —CR7R8—S(O)z—, —CR7R8—NR9—, —C(O)—CR10R11—, —C(O)—O—, —C(O)—NR9—, —O—CR10R11—, —O—C(O)—, —S(O)z—CR10R11—, —S(O)2—NR9—, —NR9—CR10R11—, —NR9—C(O)—, and —NR9—S(O)2—; A1 is a C3-10 carbocyclic ring or a 3 to 10 membered heterocyclic ring; A2 is phenyl, naphthyl, or a heteroaryl ring; A3 is phenyl, naphthyl, or a heteroaryl ring; R1 is hydrogen, C1-6 alkyl, or combines with R2 to form a fused monocyclic C3-7 carbocyclic ring or a 3 to 7 membered heterocyclic ring; R2 and R3 are independently hydrogen or halogen, or R3 is hydrogen and R2 combines with R1 to form a fused monocyclic C3-7 carbocyclic ring or a 3 to 7 membered heterocyclic ring; R4 at each occurrence is independently selected from the group consisting of halogen, —CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, —OH, ═O, —OR12, —S(O)ZR12, —C(O)R12, —NR13R14, and ═NR14, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl are optionally substituted with one or more fluoro, —OH, —NH2, —ORa, —S(O)zRa, —C(O)Ra, —NHRa, —NRaRb, or optionally fluoro substituted C3-6 cycloalkyl; R5 and R6 at each occurrence are independently selected from the group consisting of halogen, —CN, —OH, —NH2, —NO2, —C(O)—OH, —C(O)—NH2, —S(O)2—NH2, and L1-R15; R7, R8, R9, R10, and R11 are independently selected from the group consisting of hydrogen and C1-6 alkyl; L1 at each occurrence is independently selected from the group consisting of a direct bond, —C(O)—, —O—, —S(O)Z, —NR16—, —C(O)—O—, —O—C(O)—, —C(O)—NR16—, —NR16—C(O)—, —S(O)2—NR16—, and —NR16—S(O)2—; R12 at each occurrence is independently selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of fluoro, —OH, —NH2, —ORa, —S(O)zRa, —C(O)Ra, —NHRa, —NRaRb, and optionally fluoro substituted C3-6 cycloalkyl; R13 and R14 at each occurrence are independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of fluoro, —OH, —NH2, —ORa, —S(O)zRa, —C(O)Ra, —NHRa, —NRaRb, and optionally fluoro substituted C3-6 cycloalkyl or R13 and R14 combine with the nitrogen to which they are attached to form a 4-7 membered monocyclic heterocyclic ring or a 5 or 7 membered heteroaryl ring, wherein said ring is optionally substituted with one or more substituents independently selected from the group consisting of halogen, —CN, ═O, —OH, —NH2, —ORa, —S(O)zRa, —C(O)Ra, —NHRa, —NRaRb, and optionally fluoro substituted C1-6 alkyl, optionally fluoro substituted C2-6 alkenyl, optionally fluoro substituted C2-6 alkynyl, and optionally fluoro substituted C3-6 cycloalkyl; R15 at each occurrence is independently selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl, 3-7 membered heterocycloalkyl, phenyl, naphthyl, and heteroaryl, wherein phenyl, naphthyl, and heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of —CN, —OH, —NO2, —C(O)—OH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl, 3-7 membered heterocycloalkyl, phenyl, 5 or 6 membered heteroaryl, —OR17, —S(O)zR17, —NR18R19, —C(O)R17, —C(O)—OR17, —O—C(O)R17, —C(O)—NR18R19, —NR16—C(O)R17, —S(O)2—NR18R19, and —NR16—S(O)2R17, and wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl, 3-7 membered heterocycloalkyl, as R15 or as a substituent of phenyl, naphthyl, or heteroaryl, are optionally substituted with one or more substituents independently selected from the group consisting of fluoro, —CN, —OH, ═O, ═NH, —NO2, —C(O)—OH, C3-6 cycloalkyl, 3-7 membered heterocycloalkyl, —OR17, —S(O)zR17, ═NR17, —NR18R19, —C(O)R17, —C(O)—OR17, —O—C(O)R17, —C(O)—NR18R19, —NR16—C(O)R17, —S(O)2—NR18R19, and —NR16—S(O)2R17; R16 at each occurrence is independently selected from the group consisting of hydrogen C1-6 alkyl; R17 at each occurrence is independently selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of fluoro, —OH, —NH2, —ORa, —S(O)zRa, —C(O)Ra, —NHRa, —NRaRb, and optionally fluoro substituted C3-6 cycloalkyl; R18 and R19 at each occurrence are independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of fluoro, —OH, —NH2, —ORa, —S(O)zRa, —C(O)Ra, —NHRa, —NRaRb, and optionally fluoro substituted C3-6 cycloalkyl, or R18 and R19 combine with the nitrogen to which they are attached to form a 4-7 membered monocyclic heterocyclic ring or a 5 or 7 membered heteraoryl ring, wherein said ring is optionally substituted with one or more substituents independently selected from the group consisting of halogen, —CN, ═O, —OH, —NH2, —ORa, —S(O)zRa, —C(O)Ra, —NHRa, —NRaRb, optionally fluoro substituted C1-6 alkyl, optionally fluoro substituted C2-6 alkenyl, optionally fluoro substituted C2-6 alkynyl, and optionally fluoro substituted C3-6 cycloalkyl; Ra and Rb at each occurrence are independently selected from the group consisting of optionally fluoro substituted C1-6 alkyl, optionally fluoro substituted C2-6 alkenyl, optionally fluoro substituted C2-6 alkynyl, and optionally fluoro substituted C3-6 cycloalkyl, or Ra and Rb combine with the nitrogen to which they are attached to form N-linked-heterocycloalkyl; m is 0, 1, or 2; n is 0, 1, 2, or 3; p is 0, 1, 2, or 3; and z is 0, 1, or 2. |
