MICROFLUIDIC CHIPS WITH MICRO-TO-MACRO SEAL AND A METHOD OF MANUFACTURING MICROFLUIDIC CHIPS WITH MICRO-TO-MACRO SEAL

摘要

A microfluidic chip for a microfluidic system includes a micro-to-macro seal. The microfluidic chip has a substrate, at least one microfluidic pathway in the substrate, and a PDMS seal layer on the substrate and above the microfluidic pathway. The PDMS seal layer provides a seal above the microfluidic pathway and prevent particles or contaminants entering the micro-channel during transportation or prior to application. During application, a needle or piping pierces through the PDMS seal layer, and fluid can be pumped into the microfluidic chip without concern for the fluid leaking despite high pressure required to pump or drive the fluid into the microfluidic pathway.

主权项

1. A method for manufacturing a microfluidic chip device, comprising:
spinning a substrate having a first thickness and at least one microfluidic pathway in the substrate; depositing a layer of liquid PDMS onto the substrate; and hardening the PDMS layer, wherein the PDMS layer has a second thickness, and the second thickness is smaller than the first thickness.