ROLE OF IFNG METHYLATION IN INFLAMMATORY BOWEL DISEASE

摘要

The invention relates to method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation. In one embodiment, the present invention provides a method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject, and diagnosing susceptibility to inflammatory bowel disease based on the presence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject. In another embodiment, the IBD is ulcerative colitis.

主权项

1. A method of diagnosing susceptibility to an inflammatory bowel disease (IBD) subtype in an individual, comprising:
(a) obtaining a sample from the individual; (b) assaying the sample to determine the presence or absence of at least one risk genetic variant at the genetic locus of IFNG; and (c) diagnosing susceptibility to the IBD subtype based on the presence of at least one risk genetic risk variant at the genetic locus of IFNG.