COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY DISORDERS

摘要

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of respiratory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants, upper respiratory infections, (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis, neuropathic pain and pain associated with fibromyalgia.

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt, hydrate, polymorph, solvate, prodrug, enantiomer, or stereoisomer thereof; wherein: R1 represents D, H, —OD3 or O; R2 represents D, H, —OD3, R3 represents a is 2, 3 or 7; each b is independently 3, 5 or 6; e is 1, 2 or 6; and c and d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3.