发明名称 |
PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS RESISTANT ANIMALS |
摘要 |
The disclosure relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD 163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided. |
申请公布号 |
EP2709445(A4) |
申请公布日期 |
2015.03.25 |
申请号 |
EP20120785983 |
申请日期 |
2012.05.16 |
申请人 |
THE CURATORS OF THE UNIVERSITY OF MISSOURI |
发明人 |
PRATHER, RANDALL, S. |
分类号 |
A01K67/027;C12N15/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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