| 摘要 |
<p>Disclosed are: a means for expressing a-Gal in a virus without using any enzyme; the production of a virus having a-Gal expressed therein by utilizing the means; the production of a vaccine from the virus; an influenza virus vaccine having a high effect (antigenicity), which is produced using a virus having enhanced immune response to a virus; and others. Specifically disclosed are: a transgenic bird which can express an a-galactose epitope (Gala1-3Galß1-4GlcNAc-R: referred to as "a-Gal", hereinafter), wherein the bird is a chicken and may be G0 or a progeny thereof; a method for producing a transgenic bird, which comprises introducing a vector that is used for the introduction of an a1,3-galactose transferase (a1,3-GT) gene and contains an a1,3-GT gene in such a manner that the gene can be expressed, into a bird, thereby producing the transgenic bird; a biological sample, such as an egg, obtained from the transgenic bird; and a method for producing an a-Gal-expressing virus, which comprises inoculating a biological sample with a virus, cultivating the biological sample that has been inoculated with the virus, and obtaining a virus capable of expressing a-Gal from the cultivated biological sample.</p> |
