| 主权项 |
1. A compound of Formula II:or a pharmaceutically acceptable salt thereof, wherein
each Z is independently either N or C—R4; A is a selected from the group consisting of
a) C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C6-C8 bridged cycloalkyl, or C6-C8 bridged cycloalkenyl,b) substituted C1-C8 alkyl, substituted C2-C8 alkenyl, substituted C2-C8 alkynyl, substituted C3-C8 cycloalkyl, substituted C6-C8 bridged cycloalkyl, or substituted C6-C8 bridged cycloalkenyl, each of which is substituted with 0, 1, 2, 3 or 4 independently selected RA, and 0 or 1 RB, provided that at least one RA substituent other than H, or an RB substituent is present;c) C1-C8 haloalkyl, C3-C8 halocycloalkyl, or C1-C8 haloalkyl substituted with RB,d) Aryl, ande) Het; J is selected from the group consisting of a direct bond, RJ is selected from the group consisting of hydrogen and C1-C6 alkyl; L is NH; G is selected from the group consisting of wherein RG is selected from the group consisting of C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C5 alkyl, or C3-C6 cycloalkyl-C1-C5 alkyl substituted with C1-C6 alkoxy; each R1 is selected from the group consisting of hydrogen, C1-C9 alkyl, C1-C6 alkyl-RB, C1-C9 hydroxylalkyl, C3-C8 cycloalky, C1-C4 haloalkyl, Aryl, and Het; R2 is selected from the group consisting of C1-C9 alkyl, C2-C9 alkenyl, C2-C9 alkynyl, C3-C8 cycloalkyl, Het, and Aryl; R3 is selected from the group consisting of C1-C9 alkyl, C2-C9 alkenyl, and C2-C9 alkynyl; T is selected from the group consisting of O, (CH2)q2, NH, SO2 and S, wherein q2 is 1 or 2; Q is —(CRA2)2 or —O—CH2—; each R4 is independently selected from the group consisting of: hydrogen, halogen, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6—alkyl-RB, C1-C6 haloalkyl-RB, C1-C6 alkoxy-RB, C1-C6 haloalkoxy —RB, C3-C8 cycloalkyl, C3-C8 cycloalkyl-C1-C9 alkyl, C1-C6 hydroxyalkyl, O—C1-C6 hydroxyalkyl, O—C1-C6 alkyl-RB, CN, O—(C1-C5 alkyl)-O—(C1-C3 alkyl), O—(C1-C5 alkyl)-O—(C1-C3 alkyl)-RB, —(C0-C3 alkyl)-O—(C0-C3 alkyl)-(C3-C8 cycloalkyl), —(C0-C3 alkyl)-S—(C0-C3 alkyl)-(C3-C8 cycloalkyl), —(C0-C3 alkyl)-S(O)2—(C0-C3 alkyl)-(C3-C8 cycloalkyl), Het, Aryl, and wherein X1 is either CH2, NH, O, or S; X2 is either CH or N; and X3 is either NH, CH2, O, or S;provided that two R4 groups can join together to form methylene dioxy;
each Aryl is independently phenyl optionally substituted with 1 or 2 RC substituents; each Het is independently either (a) 4-, 5- or 6-membered saturated or unsaturated monocyclic ring with 1 or 2 heteroatom ring atoms independently selected from the group consisting of N, O and S; or (b) 8-, 9- or 10-membered saturated or unsaturated bicyclic ring with 1, 2, or 3 heteroatom ring atoms independently selected from the group consisting of N, O and S, provided that said Het is optionally substituted with 1 or 2 RC substituents; each RA is independently selected from the group consisting of: H, F, Cl, Br, I, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 alkyl(NH2), C6-C8 bridged cycloalkyl, C3-C8 cycloalkyl, C1-C6 haloalkoxy, C3-C8 halocycloalkyl, SH, S(C1-C6 alkyl), NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl)2, C(O)(C1-C6 alkyl), C(O)(C3-C8 cycloalkyl), CONH2, SO2NH2, NO2, CN, CF3, CHF2, CH2F, OCHF2, OCF3, OCH2F, SO2(C1-C6 alkyl), S(O)(C1-C6 alkyl), —(C1-C6 alkyl)S(O)(C1-C6 alkyl), SO2(C3-C6 cycloalkyl), —(C1-C6 alkyl)S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)N(C1-C6 alkyl)SO2(C1-C6 alkyl), N(C1-C6 alkyl)SO2(C1-C6 alkyl), SO2N(C1-C6 alkyl)2, —(C1-C6 alkyl)SO2N(C1-C6 alkyl)2, NHCOO(C1-C6 alkyl), NHCO(C1-C6 alkyl), NHCONH(C1-C6 alkyl), CO2(C1-C6 alkyl), C(O)N(C1-C6 alkyl)2, —(C0-C5 alkyl)-(C3-C8 cycloalkyl), —(C0-C5 alkyl)-O—(C0-C5 alkyl)-(C3-C8 cycloalkyl), —(C0-C5 alkyl)-S—(C0-C5 alkyl)-(C3-C8 cycloalkyl),—(C0-C5 alkyl)-S(O)2—(C0-C5 alkyl)-(C3-C8 cycloalkyl), Aryl, and Het; provided that two RA groups present on adjacent carbon atoms can together with the adjacent carbon atoms form a C3-C6 cycloalkyl;
each RB is independently either Het or Aryl; each RC is independently either halogen, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl or C1-C6 haloalkyl; alternatively, with respect to A and R1, A is either C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, or C3-C8 cycloalkyl, each of which is substituted with RA1, and RA1 in combination with R1 forms a C3-C8 alkylene, a C3-C8 alkenylene, or a C3-C8 alkynylene; alternatively, with respect to A and R2, A is either C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, or C3-C8 cycloalkyl, each of which is substituted with RA1, and RA1 in combination with R2 form a C3-C8 alkylene, a C3-C8 alkenylene, or a C3-C8 alkynylene; alternatively, with respect to R2 and R3, R2 and R3 form a C3-C8 alkylene, C3-C8 alkenylene, or C3-C8 alkynylene. |
