| 主权项 |
1. A compound represented by Formula I, its enantiomers, diastereoisomers, tautomers, or a pharmaceutically acceptable salt thereof,wherein:
R1 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14; R2 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14; R3 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14; R4 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14; R5 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14; R6 is H, optionally substituted C6-10 aryl, optionally substituted heterocycle or optionally substituted C1-6 alkyl; R7 is H, OH, OC1-6 alkyl or optionally substituted C1-6 alkyl; R8 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14,R9 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R10 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R11 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R12 is H or optionally substituted C1-6 alkyl;R13 is H or optionally substituted C1-6 alkyl;R14 is H or optionally substituted C1-6 alkyl;X is O, CH2, NR12 or S;a is 0, 1, 2 or 3;b is 0, 1, 2 or 3;Z is OPO3H2, carboxylic acid, PO3H2, —P(O)MeOH, —P(O)(H)OH or OR15; andR15 is H, C(O)R7 or optionally substituted C1-6 alkyl. |
