| 发明名称 |
Vaccine for prophylaxis or treatment of an allergen-driven airway pathology |
| 摘要 |
The present invention relates to a life attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for prophylaxis or treatment of an allergen-driven airway pathology. |
| 申请公布号 |
US8986709(B2) |
申请公布日期 |
2015.03.24 |
| 申请号 |
US201313782754 |
申请日期 |
2013.03.01 |
| 申请人 |
INSERM (Institut National de la Sante et de la Recherche Medicale);Institut Pasteur de Lille;National University of Ireland Maynooth |
发明人 |
Locht Camille;Mahon Bernard;Kavanagh Heather |
| 分类号 |
A61K39/10 |
主分类号 |
A61K39/10 |
| 代理机构 |
|
代理人 |
Kim Stanley A. |
| 主权项 |
1. A method for reducing airway inflammation in a subject which develops airway inflammation in response to exposure to an allergen, the method comprising the step of infecting the subject with a live Bordetella pertussis strain which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT), wherein the step of infecting the subject results in reduction of airway inflammation in said subject. |
| 地址 |
Paris FR |
