Method to increase the absorption of unsaturated fatty acids by human infants

摘要

The present invention relates to a method to increase the absorption by a human infant of at least one unsaturated fatty acid, said method comprising the enteral administration to said infant of recombinant human bile-salt-stimulated lipase (rhBSSL). In another aspect the invention also relates to a method to improve the visual and/or cognitive development of a human infant, said method comprising the enteral administration to said infant of rhBSSL. Such methods have particular utility for preterm human infants, particular those in medical need of increasing their absorption of or availability to such unsaturated fatty acids. In further aspects, the invention relates to kits, packaged-pharmaceutical-products, recombinant human bile-salt-stimulated lipase and pharmaceutical compositions, in each case useful for increasing the absorption by a human infant of at least one unsaturated fatty acid, or for increasing the visual and/or cognitive development of a human infant.

主权项

1. A method to increase the absorption by a preterm human infant of at least one unsaturated fatty acid from infant formula or pasteurized human milk, said method comprising:
enteral administration of 1 to 100 mg per kg of infant of a recombinant human bile-salt-stimulated lipase to said preterm infant, wherein said infant is from about 21 to 37 weeks of gestation.