| 摘要 |
This invention provides compounds of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and or salts thereof, pharmaceutical compositions comprising a compound of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type II diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and intermediates useful in the preparation of same. |
| 主权项 |
1. A compound represented by Formula (I):or a pharmaceutically acceptable salt thereof, wherein:
X, Y and Z are independently selected from the group consisting of hydrogen, halogen, CN, C1-4 alkyl, C1-3 hydroxyalkyl, and C1-3 haloalkyl, with the proviso that at least one of X, Y and Z is not hydrogen; each Ra is independently selected from halogen, C1-4 alkyl (wherein said C1-4 alkyl is optionally substituted with from 1-2 substituents each independently selected from CN, OH and OC1-3 alkyl), and C1-5 haloalkyl; Rb is independently selected from C1-4 alkyl (wherein said C1-4 alkyl is optionally substituted with from 1-2 substituents each independently selected from the group consisting of CN, OH and OPh (wherein said Ph is optionally substituted with 1-2 substituents each independently selected from the group consisting of halogen, OH, CN and OC1-3 alkyl)) and C1-5 haloalkyl; A is a 2-5 membered carbon alkyl linker selected from the group consisting ofandn is 0, 1, 2 or 3. |
