| 发明名称 | Potent and selective mediators of cholesterol efflux | ||
| 摘要 | The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation. | ||
| 申请公布号 | US8987192(B2) | 申请公布日期 | 2015.03.24 |
| 申请号 | US200712519116 | 申请日期 | 2007.12.13 |
| 申请人 | The Regents of the University of California | 发明人 | Bielicki John K.;Johansson Jan |
| 分类号 | A61K38/00;A61K38/16;A61K45/00;A61K47/24;A61K49/00;A61K51/00;A61K9/127;C07K14/00;C07K14/47;C07K14/705;A61P3/06;A61P9/00;C07K14/775 | 主分类号 | A61K38/00 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. An isolated polypeptide having cholesterol efflux and ABCA1 stabilizing activity, wherein the peptide comprises an amphipathic α-helix segmentX1X2X3X4X5X6X7X8X9X10X11X12X13X14X15X16X17X18X19X20X21X22X23X24having at least 60% identity to EVRSKLEEWFAAFREFAEEFLARL (SEQ ID NO:12); and X1, X7, X8, X15, X18 and X19 are amino acids independently selected from the group consisting of D and E. | ||
| 地址 | Oakland CA US | ||