| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention concerns a method for preparing spiro-oxyindole derivatives of formula 1or its pharmaceutically acceptable salt in the form of a separate stereoisomer, or enantiomer, or a mixture thereof, containing a) preparing a compound of formula(7) or its pharmaceutically acceptable salt by the compound in the acceptable conditions to form the compound of formula(8) or its pharmaceutically acceptable salt and b) processing the compound of formula (8) or its pharmaceutically acceptable salt by the compound of formula(9) or its pharmaceutically acceptable salt in the appropriate environment to prepare the compound of formula (I) or its pharmaceutically acceptable salt in the form of a separate stereoisomer, or enantiomer, or a mixture thereof.EFFECT: compounds of formula 1 are effective in treating and/or preventing sodium channel mediated diseases or conditions, such as pain.6 cl, 2 tbl, 5 ex |
