USE OF BIOMARKERS IN THE ASSESSMENT OF THE EARLY TRANSITION FROM ARTERIAL HYPERTENSION TO HEART FAILURE

摘要

Methods and systems for diagnosing functional and/or structural abnormalities of the heart preceding heart failure, and for predicting the risk of developing heart failure, in a subject comprising measuring a cardiac troponin in a sample and comparing the measurement to a reference value. Other markers, including GDF15 and IGFBP7 are also measured in some embodiments.

主权项

1. A method of diagnosing a heart functional or structural abnormality preceding heart failure in a subject, the method comprising the steps of:
a) contacting, in vitro, a portion of a sample of the subject with an antibody having specific binding affinity for an epitope of a cardiac troponin marker or variant thereof, whereby a complex of the antibody and the cardiac troponin marker or variant thereof is formed; b) calculating a concentration of the cardiac troponin marker or variant thereof in the sample based on an amount of complex formed in said step of contacting; c) comparing the concentration of the cardiac troponin marker or variant thereof determined in said step of calculating with a cardiac troponin marker reference value; and d) diagnosing a heart functional or structural abnormality preceding heart failure in the subject if the concentration of the cardiac troponin marker or variant thereof in the sample is greater than the cardiac troponin marker reference value.