IDENTIFICATION OF NON-RESPONDERS TO HER2 INHIBITORS

摘要

The present invention relates to means and methods for the identification of non-responders to a HER2 inhibitor, whereby one or more mutations in exon 9 of Phosphoinositol-3 kinase (PIK3CA) indicate non-responsiveness.

主权项

1. A method for identifying a non-responder to a HER2-inhibitor, said method comprising evaluating the presence of one or more mutations in the catalytic subunit of Phosphoinositol-3 kinase (PIK3CA or p110α) in a sample from a patient with HER2-positive cancer; wherein the presence of mutations in exon 9 is evaluated and the presence of mutations in exon 20 is not evaluated,
whereby the presence of one or more mutations in exon 9 indicates non-responsiveness of said patient to said HER2 inhibitor.