IMAGING AGENTS AND METHODS OF IMAGING NAALADASE OR PSMA

摘要

The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express NAALADase and/or PSMA to which the compounds of the invention have an affinity.

主权项

1. A compound according to Formula I wherein R is selected from the group consisting of fluoroalkyl, aryl, benzyl, thiol, and alkylthiol, each of which is optionally substituted with an optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted alkanoyl, or optionally substituted aralky, optionally substituted alkoxy, optionally substituted aralkyloxy, or optionally substituted phenoxy; Q is hydrogen, optionally substituted alkyl, optionally substituted benzyl or optionally substituted phenyl; and Z is Q or a tetrazole; or a pharmaceutically acceptable salt thereof.