COMPOUNDS FOR INHIBITION OF MEMAPSIN 1

摘要

Various embodiments of the present invention relate to, among other things, compounds that are inhibitors of Memapsin 1 and, as a result, are effective in the treatment of Alzheimer's disease or diabetes (e.g., Type 2 diabetes).

主权项

1. A compound of the formula (Ia)-(Ic): or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: Ar1 and Ar2 are each independently substituted or unsubstituted aryl; R1 is hydrogen, alkyl or arylalkyl; R2, R4, and R6 are each, independently, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted arylalkyl; R3 is hydrogen, substituted or unsubstituted alkyl or —NR82 (wherein each R8 is, independently, hydrogen, substituted or unsubstituted alkyl or substituted or unsubstituted arylalkyl or —SO2R9, wherein R9 is hydrogen or substituted or unsubstituted alkyl); and R5 and R7 are each independently hydrogen, substituted or unsubstituted alkyl or substituted or unsubstituted arylalkyl.