EVOKING PROTECTION AGAINST STREPTOTOCCUS PNEUMONIAE INCORPORATING B-CELL AND T-CELL PNEUMOCOCCAL PROTEIN ANTIGENS AND PNEUMOCOCCAL POLYSACCHARIDES DELIVERED CONCOMITANTLY

摘要

This disclosure is directed to compositions that combine the polysaccharide-specific antibody protection afforded by the conventional vaccines through carrier effects provided by one or more pneumococcal common T-cell antigen(s) together with Streptococcus pneumoniae-specific Th-17 responses elicited by the pneumococcal carrier common T-cell antigen. The disclosed compositions are useful for pan-serotypic protection against NP carriage, and antibody responses against common pneumococcal virulence factors, potentially useful for pan-serotype protection against Streptococcus pneumoniae invasive diseases.

主权项

1. A method of generating an immune response against Streptococcus pneumoniae, comprising administering to a subject in need a therapeutically effective amount of an immunogenic composition, wherein the immunogenic composition comprises:
a plurality of different S. pneumoniae capsular polysaccharides (CPs) from S. pneumoniae serotypes 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, or 33F; a first polypeptide antigen with an amino acid sequence at least 90% identical to the polypeptide sequence of an antigen listed in Table 2, or an immunogenic fragment thereof; or a second polypeptide antigen with an amino acid sequence at least 90% identical to the polypeptide sequence of an antigen listed in Table 1, or an immunogenic fragment thereof; wherein the plurality of CPs are conjugated to the first polypeptide antigen.