| 摘要 |
<p>The present invention discloses novel cyclohexane derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention discloses a compound represented by the formula (I), or a pharmaceutically acceptable salt or a solvate thereof:
wherein A is substituted or unsubstituted aryl or heterocyclyl; a combination of X and Y is a combination selected from (X, Y)=(C(=O)N(R 1 ), C(=O)N(R 2 )), (C(=O)N(R 1 ), imidazole-1,3-diyl), (N(R 1 ), C(=O)N(R 2 )), (O, C(=O)N(R 2 )), (C(R 3 )(R 4 ), N(R 2 )) or (a single bond, C(=O)N(R 2 )); R 1 , R 2 and R 3 are independently hydrogen or substituted or unsubstituted alkyl; R 5 is substituted or unsubstituted aryl or heterocyclyl; R 6 is halogen, oxo, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy; m is 0 or 1; and n is an integer of 0 to 5; and B is aromatic carbocycle, monocyclic heterocycle or fused bicyclic heterocycle.</p> |
