Polypeptide solution, artificial polypeptide fiber production method and polypeptide purification method using same

摘要

A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.

主权项

1. A polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent,
wherein the solvent contains at least one selected from the following (i)-(iii): (i) Dimethyl sulfoxide; (ii) Dimethyl sulfoxide with an inorganic salt; and (iii) N, N-dimethylformamide with an inorganic salt.