发明名称 |
Treatment with a pharmaceutical composition comprising MANF2 necleic acid |
摘要 |
A method for treating a condition in a patient, wherein the condition is selected from the group consisting of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke and peripheral neuropathy. The method consists of administering to the patient a pharmaceutically effective amount of a pharmaceutical composition comprising the MANF2 polypeptide of SEQ ID NO:2 or a functional fragment thereof. |
申请公布号 |
US8980821(B2) |
申请公布日期 |
2015.03.17 |
申请号 |
US201113088233 |
申请日期 |
2011.04.15 |
申请人 |
Herantis Pharma Oyj |
发明人 |
Saarma Mart;Lauren Juha;Lindholm Päivi;Timmusk Tonis;Tuominen Raimo |
分类号 |
A61K38/17;C07K14/435 |
主分类号 |
A61K38/17 |
代理机构 |
Birch, Stewart, Kolasch & Birch, LLP |
代理人 |
Birch, Stewart, Kolasch & Birch, LLP |
主权项 |
1. A method of treating the symptoms of Parkinson's disease in a patient in need thereof, the method comprising:
directly administering to the central nervous system of the patient a pharmaceutically effective amount of a pharmaceutical composition comprising the MANF2 polypeptide of SEQ ID NO:2 or a functional fragment thereof, wherein said functional fragment is capable of preventing the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons, and wherein said functional fragment comprises amino acids 27-187 of the amino acid sequence of SEQ ID NO:2. |
地址 |
Helsinki FI |