发明名称 |
Glucagon antagonists |
摘要 |
Glucagon antagonists are provided which comprise amino acid substitutions and/or chemical modifications to glucagon sequence. In one embodiment, the glucagon antagonists comprise a native glucagon peptide that has been modified by the deletion of the first two to five amino acid residues from the N-terminus and (i) an amino acid substitution at position 9 (according to the numbering of native glucagon) or (ii) substitution of the Phe at position 6 (according to the numbering of native glucagon) with phenyl lactic acid (PLA). In another embodiment, the glucagon antagonists comprise the structure A-B-C as described herein, wherein A is PLA, an oxy derivative thereof, or a peptide of 2-6 amino acids in which two consecutive amino acids of the peptide are linked via an ester or ether bond. |
申请公布号 |
US8981047(B2) |
申请公布日期 |
2015.03.17 |
申请号 |
US200812739342 |
申请日期 |
2008.10.23 |
申请人 |
Indiana University Research and Technology Corporation |
发明人 |
Dimarchi Richard D.;Yang Bin |
分类号 |
A61K38/26;C07K14/605;C07K14/00;A61K38/00 |
主分类号 |
A61K38/26 |
代理机构 |
Barnes & Thornburg LLP |
代理人 |
Barnes & Thornburg LLP |
主权项 |
1. A glucagon antagonist comprising the sequence of SEQ ID NO: 42, or an oxy derivative thereof. |
地址 |
Indianapolis IN US |