METHODS FOR GENETICALLY DIVERSIFIED STIMULUS-RESPONSE BASED GENE ASSOCIATION STUDIES

摘要

Methods are provided for improving the impact of genetically diversified stimulus response gene association (GDSRGA) studies. The methods may involve developing subpopulations to be contrasted in GDSRGA studies by obtaining a biological sample from each donor of a population of donors; selecting a common cohort from the biological samples by obtaining at least a partial genomic sequence from each biological sample, aligning the sequences of the biological samples, and removing biological samples that cannot be sequenced accurately or fail to align; applying a test molecule or condition to the biological samples to induce phenotypically distinct responses among the members of the cohort; and segregating the biological samples into subpopulations based on the phenotypically distinct responses. These subpopulations may be used in GDSRGA studies.