发明名称 |
METHOD FOR IMPROVING ANTIBODY STABILITY |
摘要 |
Herein is reported a method for selecting or deselecting an antibody comprising a) determining for each Asp and Asn residue in an antibody Fv region the conformational flexibility of the Ca-atom using a homology model ensemble, b) determining for each Asp and Asn residue in an antibody Fv region the size of the amino acid residue C-terminal to the Asp or Asn residue, and c) selecting an antibody in which the Ca-atom is conformationally inflexible and/or the Asp or Asn has a big C-terminal amino acid residue, or deselecting an antibody in which the Ca-atom has a moderate to high conformational flexibility and/or the Asp or Asn has a small C-terminal amino acid residue. |
申请公布号 |
CA2918191(A1) |
申请公布日期 |
2015.03.12 |
申请号 |
CA20142918191 |
申请日期 |
2014.09.03 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
KETTENBERGER, HUBERT;KLOSTERMANN, STEFAN;LIPSMEIER, FLORIAN;PAPADIMITRIOU, APOLLON;SYDOW-ANDERSEN, JASMIN |
分类号 |
G01N33/68;G06F19/16 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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