发明名称 |
EMETINE DERIVATIVES, PRODRUGS CONTAINING SAME, AND METHODS OF TREATING CONDITIONS USING SAME |
摘要 |
Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2′-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia. |
申请公布号 |
EP2712361(A4) |
申请公布日期 |
2015.03.11 |
申请号 |
EP20120789195 |
申请日期 |
2012.05.18 |
申请人 |
HOWARD UNIVERSITY |
发明人 |
BAKARE, OLADAPO;DENMEADE, SAMUEL, RAY;AKINBOYE, EMMANUEL |
分类号 |
C07D455/08;A61K31/4725;A61K47/48;C07D401/06 |
主分类号 |
C07D455/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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