| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: method involves contacting trans-4-aminocyclohexanole with BOC-anhydride (di-tert-butyldicarbonate) in the presence of a solvent, and optionally in the presence of a base for preparing a compound of formula A, contacting the compound of formula A with methansulphonyl chloride in the presence of the solvent and optionally in the presence of the base for preparing a compound of formula B, contacting the compound of formula B with trifluoroacetic acid in the presence of the solvent for preparing a compound of formula Cand contacting the compound of formula C with hydroxide in the presence of the solvent for preparing the compound of formula 7. Described is a method for preparing the compound of formula 7ainvolving contacting the compound 7 with HCl.EFFECT: invention refers to a method for preparing the compound 7or its pharmaceutically acceptable salt, which is effective as an intermediate for preparing pharmaceutical compounds.16 cl, 1 dwg |
