发明名称 |
Method for treating or preventing bladder cancer using the DEPDC1 polypeptide |
摘要 |
The present invention provides therapeutic agents and methods for treating cancer using the polypeptides composed of an amino acid sequence which includes a polypeptide fragment of DEPDC1. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine. Furthermore, the present invention provides methods of screening for therapeutic agents or compounds useful in inhibition of the DEPDC1/ZN-F224 complex formation or the treatment of cancer. The present invention also provides siRNAs targeting the ZNF224 gene, which are suggested to be useful in the treatment of bladder cancer. |
申请公布号 |
US8975086(B2) |
申请公布日期 |
2015.03.10 |
申请号 |
US200913061064 |
申请日期 |
2009.08.21 |
申请人 |
OncoTherapy Science, Inc. |
发明人 |
Nakamura Yusuke;Katagiri Toyomasa;Togashi Akira |
分类号 |
G01N33/53;A61K38/00;C07K7/00;C07K14/00;C07K14/82;C12N15/113;G01N33/50;A61K48/00 |
主分类号 |
G01N33/53 |
代理机构 |
Kilpatrick Townsend & Stockton LLP |
代理人 |
Kilpatrick Townsend & Stockton LLP |
主权项 |
1. A method of screening for a candidate compound for treating a cancer associated with DEPDC1 or inhibiting the binding between DEPDC1 and ZNF224, said method comprising the steps of:
(a) contacting a DEPDC1 polypeptide or functional equivalent thereof which comprises the amino acid sequence of SEQ ID NO: 28, 54 or 55 with a ZNF224 polypeptide, in the presence of a test compound; (b) detecting the binding between the polypeptides; and (c) selecting the test compound that inhibits the binding between these polypeptides. |
地址 |
Kanagawa JP |