| 发明名称 | Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors | ||
| 摘要 | The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. | ||
| 申请公布号 | US8975382(B2) | 申请公布日期 | 2015.03.10 |
| 申请号 | US200812744991 | 申请日期 | 2008.11.27 |
| 申请人 | Ablynx N.V. | 发明人 | Revets Hilde Adi Pierrette;Boutton Carlo;Hoogenboom Hendricus Renerus Jacobus Mattheus |
| 分类号 | C07K16/30;C07K16/32;C07K16/46;C07K16/28 | 主分类号 | C07K16/30 |
| 代理机构 | Wolf, Greenfield & Sacks, P.C. | 代理人 | Wolf, Greenfield & Sacks, P.C. |
| 主权项 | 1. Isolated amino acid sequence that specifically binds HER2 and inhibits binding of trastuzumab to HER2, and that essentially consists of 4 framework regions (FR1 to FR4, respectively) and 3 complementarity determining regions (CDR1 to CDR3, respectively), in which: CDR1 is SEQ ID NO:462, and CDR2 is SEQ ID NO:1012, and CDR3 is SEQ ID NO:1562. | ||
| 地址 | Zwijnaarde BE | ||