发明名称 |
Production of Near Monodisperse Particles using Milling and Membrane Separation |
摘要 |
The present invention provides a method for producing particles having a reduced particle size distribution, which method comprises the steps of: a) providing a composition comprising particles; b) subjecting the particles in said composition to a size reduction step or to a size growth step; c) feeding said particles to a first membrane separation system to separate said particles according to size; d) recycling those particles that do not meet the size criteria back to step a); e) optionally, collecting in a collection tank the permeate of the first membrane separation system. Particles obtainable according to the method of the invention and characterized by having a near monodisperse particle size distribution are also provided. The particles are preferably characterized by having a particle size distribution with a span of less than 2.0. The invention also provides pharmaceutical compositions comprising particles according to the invention, and also apparatus for carrying out the method of the invention. |
申请公布号 |
US2015060581(A1) |
申请公布日期 |
2015.03.05 |
申请号 |
US201314389117 |
申请日期 |
2013.03.28 |
申请人 |
Hovlone International Ltd |
发明人 |
Santos José Luis;Gaspar Filipe |
分类号 |
B01D61/16;B01D61/18;B01D63/08;A61K9/14;B07B1/00;B02C23/18;B02C23/08;B01D61/14;B03B7/00 |
主分类号 |
B01D61/16 |
代理机构 |
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代理人 |
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主权项 |
1. A method for producing particles having a reduced particle size distribution, which method comprises the steps of:
a) providing a composition comprising particles; b) subjecting the particles in said composition to a size reduction step or to a size growth step; c) feeding said particles to a first membrane separation system to separate said particles according to size; d) recycling those particles that do not meet the size criteria back to step a); e) optionally, collecting in a collection tank the permeate of the first membrane separation system. |
地址 |
Wanchai, Hong Kong HK |