Extracorporeal devices and methods of treating complications of pregnancy

摘要

The invention features extracorporeal methods for the treatment of a subject having a pregnancy related hypertensive disorder, such as pre-eclampsia or eclampsia. The invention also features devices used for the extracorporeal treatment of subjects have a pregnancy related hypertensive disorder, such as pre-eclampsia or eclampsia.

主权项

1. A method of treating or ameliorating at least one symptom of a pregnancy related hypertensive disorder in a pregnant subject having elevated soluble Flt-1 (sFlt-1) levels, said method comprising the step of extracorporeally removing sFlt-1 from the pregnant subject, wherein said removing comprises an apheresis procedure, wherein said apheresis procedure comprises the use of dextran sulfate to bind said sFlt-1, wherein said apheresis procedure is sufficient to treat or ameliorate at least one symptom of a pregnancy related hypertensive disorder.