发明名称 |
Methods and compositions for the induction of hypothermia |
摘要 |
Provided herein are methods for the induction of hypothermia and the treatment of clinical insults in a subject through the administration of a regulated hypothermic multidrug combination. The compositions or multidrug combinations of the invention comprise a regulated hypothermic compound or a dopamine receptor agonist; a vasoactive compound; and an antiarrhythmic compound or a serotonin 5-HT3 receptor antagonist. Additional agents can be included in the composition including at least one of an antioxidant, a vitamin, N-acetylcysteine, and an antihyperglycemic compound. The invention further recognizes that a two phase delivery of multidrug combinations, a rapid infusion of the composition to induce hypothermia followed by a period of slow infusion to maintain the hypothermic state for a sustained period of time. Using the two phase delivery method of the invention, the composition may comprise ethanol and, optionally, at least one of a vasoactive compound, an antiarrhythmic compound, a serotonin 5-HT3 receptor antagonist, an antioxidant, a vitamin, N-acetylcysteine, and an antihyperglycemic compound. This two phase delivery method can be used to deliver any of the compositions of the invention and provides significant benefits to a patient. |
申请公布号 |
US8969297(B2) |
申请公布日期 |
2015.03.03 |
申请号 |
US201013377257 |
申请日期 |
2010.06.09 |
申请人 |
The University of North Carolina at Chapel Hill |
发明人 |
Katz Laurence M. |
分类号 |
A61K35/12;A61K38/11;A61K38/28;A61P9/10;A61P9/00;A61P25/00;A61K31/045;A61K31/167;A61K31/395 |
主分类号 |
A61K35/12 |
代理机构 |
Alston & Bird LLP |
代理人 |
Alston & Bird LLP |
主权项 |
1. A method of inhibiting, reducing, or reversing the damage due to an ischemic insult in a subject, said method comprising administering intravenously to said subject a therapeutically effective amount of a composition comprising ethanol, vasopressin, and lidocaine, wherein said composition is administered to induce regulated hypothermia in said subject, during or following said ischemic insult. |
地址 |
Chapel Hill NC US |