Method for 3-D Printing a Custom Bone Graft

摘要

A method for producing bone grafts using 3-D printing is employed using a 3-D image of a graft location to produce a 3-D model of the graft. This is printed using a 3-D printer and an ink that produces a porous, biocompatible, biodegradable material that is conducive to osteoinduction. This is porous poly methyl methacrylate (PMMA) made osteoinductive by demineralized bone (DMB). The ink is provided as a precursor powder and liquid. The powder contains DMB, sucrose crystals and a polymerization initiator. The liquid contains methyl methacrylate (MMA). Optional compounds include antibiotics, radio-pacifiers, and compounds to increase biodegradability. Once mixed, the MMA polymerizes to PMMA. The ingredients are proportioned so that the ink is delivered through a 10 gauge print nozzle for about 10 minutes per batch. Once the graft is placed, natural bone gradually replaces the graft.

主权项

1. A method for producing a custom bone graft, comprising:
obtaining a 3-D image of an intended graft location; creating a 3-D digital model of said custom bone graft using said 3-D image; and creating, using a 3-D printer said custom bone graft using an ink that dries or reacts to form a porous, biodegradable, biocompatible material that is conducive to osteoinduction and has a load bearing strength comparable to bone.