NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS

摘要

The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.

主权项

1. A process for the preparation of article of manufacture, the process comprising (1) depositing a polymeric primer on the substrate, the polymeric primer having a thickness of at least 50 nm, and (2) grafting a polymer from or to the polymeric primer, the polymeric primer being between the grafted polymer and the substrate and having upper and lower surfaces, the lower surface covering at least a portion of the substrate, and the upper surface being covalently bound to the grafted polymer, the polymeric primer and the grafted polymer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in a composition containing 70 μg/ml fibrinogen derived from human plasma and 1.4 μg/ml I-125 radiolabeled fibrinogen, provided the article is other than a polyurethane rod.