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1. A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein:
A is 4 to 7-membered monocyclic heterocycloalkyl, 7 to 11-membered bicyclic heterocycloalkyl or R15, wherein said 4 to 7-membered monocyclic heterocycloalkyl group or said 7 to 11-membered bicyclic heterocycloalkyl can be optionally and independently substituted on one or more ring nitrogen atoms with R4, and on one or more ring carbon atoms with R12, such that two R12 groups on the same ring carbon atom, together with the carbon atom to which they are attached, can join to form a spirocyclic 3 to 7-membered cycloalkyl group or a spirocyclic 4 to 7-membered heterocycloalkyl group;B is a 5-membered monocyclic heteroarylene or 9-membered bicyclic heteroarylene, wherein said 5-membered monocyclic heteroarylene group and said 9-membered bicyclic heteroarylene group can be optionally and independently substituted on one or more ring nitrogen atoms with R6 and on one or more ring carbon atoms with R12;C is a bond, phenylene, naphthylene, 5-membered monocyclic heteroarylene or 9-membered bicyclic heteroarylene, wherein said phenylene group, said naphthylene group, said 5-membered monocyclic heteroarylene group or said 9-membered bicyclic heteroarylene group can be optionally and independently substituted on one or more ring nitrogen atoms with R6 and on one or more ring carbon atoms with R12;D is 4 to 7-membered monocyclic heterocycloalkyl, 7 to 11-membered bicyclic heterocycloalkyl or R15, wherein said 4 to 7-membered monocyclic heterocycloalkyl group or said 7 to 11-membered bicyclic heterocycloalkyl group can be optionally and independently substituted on one or more ring nitrogen atoms with R4, and on one or more ring carbon atoms with R12, such that two R12 groups on the same ring carbon atom, together with the carbon atom to which they are attached, can join to form a spirocyclic 3 to 7-membered cycloalkyl group or a spirocyclic 4 to 7-membered heterocycloalkyl group, such that at least one of A and D is R15;each occurrence of R1 is independently C1-C6 alkyl, C1-C6 haloalkyl, 3-to 7-membered cycloalkyl, 4- to 7-membered heterocycloalkyl, aryl or heteroaryl, wherein said 3- to 7-membered cycloalkyl group, said 4- to 7-membered heterocycloalkyl group, said aryl group or said heteroaryl group can be optionally substituted with up to three groups, which can be the same or different, and are selected from C1-C6 alkyl, 3- to 7-membered cycloalkyl, 4- to 7-membered heterocycloalkyl, aryl, heteroaryl, halo, C1-C6 haloalkyl, —Si(R13)3, —CN, —OR3, —N(R3)2, —C(O)R10, —C(O)OR3, —C(O)N(R3)2, —NHC(O)R10, —NHC(O)NHR3, —NHC(O)OR3, —OC(O)R10, —SR3 and —S(O)2R10;each occurrence of R2 is independently H, C1-C6 alkyl, —C1-C6 haloalkyl, 3 to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl, C1-C6 hydroxyalkyl, —OH, —O—(C1-C6 alkyl), halo, —CN, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —NHC(O)—(C1-C6 alkyl), —C(O)NH—(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)2, or —Si(R13)3;each occurrence of R3 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, —C1-C6 alkylene-OC(O)(C1-C6 alkyl), C1-C6 hydroxyalkyl, 3 to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl, aryl or heteroaryl wherein said 3- to 7-membered cycloalkyl group, said 4- to 7-membered heterocycloalkyl group, said aryl group or said heteroaryl group can be optionally and independently substituted with up to three groups independently selected from —OH, halo, C1-C6 alkyl, C1-C6 haloalkyl, —NH(C1-C6 alkyl) and —N(C1-C6 alkyl)2;each occurrence of R4 is independently H, —C1-C6 alkyl, C1-C6 haloalkyl, —C(O)R1, —C(O)OR1, —C(O)CH(R7)NHC(O)OR1 or —C(O)—CH(R7)—N(R1)2;each occurrence of R5 is independently H, C1-C6 alkyl, —Si(R13)3, 3- to 7-membered cycloalkyl, 4- to 7-membered heterocycloalkyl, aryl or heteroaryl;each occurrence of R6 is independently H, C1-C6 alkyl, 3- to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl, aryl or heteroaryl, wherein said 3- to 7-membered cycloalkyl group, said 4- to 7-membered heterocycloalkyl group, said aryl group or said heteroaryl group can be optionally and independently substituted with up to two R8 groups, and wherein two R6 groups that are attached to a common nitrogen atom, together with the nitrogen atom to which they are attached, can optionally join to form a 4- to 7-membered heterocycloalkyl group;each occurrence of R7 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, benzyl, -alkylene-O—(C1-C6 alkyl), silylalkyl, 3- to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl, aryl or heteroaryl, wherein said benzyl group, said 3- to 7-membered cycloalkyl group, said 4- to 7-membered heterocycloalkyl group, said aryl group or said heteroaryl group can be optionally and independently substituted with up to three R8 groups;each occurrence of R8 is independently H, C1-C6 alkyl, halo, —C1-C6 haloalkyl, C1-C6 hydroxyalkyl, —OH, —C(O)NH—(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)2, —O—(C1-C6 alkyl), —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2 and —NHC(O)—(C1-C6 alkyl) or —Si(R13)3;each occurrence of R10 is independently C1-C6 alkyl, C1-C6 haloalkyl, 3 to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl, aryl, or heteroaryl;each occurrence of R12 is H, C1-C6 alkyl, C1-C6 haloalkyl, 3 to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl, aryl, heteroaryl, halo, —CN, —OR3, —N(R3)2, —C(O)R10, —C(O)OR3, —C(O)N(R3)2, —NHC(O)R10, —NHC(O)NHR3, —NHC(O)OR3, —OC(O)R10, —SR3, —S(O)2R10 or Si(R13)3 and wherein two R12 groups together with the carbon atom(s) to which they are attached, can optionally join to form a 5 to 7-membered cycloalkyl or 4- to 7-membered heterocycloalkyl ring;each occurrence of R13 is independently selected from C1-C6 alkyl, 3- to 7-membered cycloalkyl, 4- to 7-membered heterocycloalkyl, aryl, heteroaryl, C1-C6 haloalkyl, —CN and —OR3, wherein two R13 groups, together with the silicon atom to which they are attached, can optionally join to form a 4- to 7-membered silicon-containing heterocycloalkyl ring; andeach occurrence of R15 is independently a monocyclic 5- to 7-membered silylheterocycloalkyl ring or a bicyclic 7- to 11-membered bicyclic silylheterocycloalkyl ring wherein said silylheterocycloalkyl rings contains as heteroatom ring members:
(i) one —Si(R13)z—;(ii) one —N(R4)—; and(iii) one optional and additional heteroatom ring member elected from the group consisting of nitrogen, oxygen and sulfur,and wherein an R15 group can be optionally and independently substituted on one or two ring carbon atoms with R12. |
